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Learn More About the Clifton StrengthsFinder Theme

Your Responsibility theme forces you to take psychological ownership for anything you commit to, and whether large or small, you feel emotionally bound to follow it through to completion. Your good name depends on it.

If for some reason you cannot deliver, you automatically start to look for ways to make it up to the other person. Apologies are not enough. Excuses and rationalizations are totally unacceptable. You will not quite be able to live with yourself until you have made restitution.

This conscientiousness, this near obsession for doing things right, and your impeccable ethics, combine to create your reputation: utterly dependable. When assigning new responsibilities, people will look to you first because they know it will get done.

When people come to you for help -- and they soon will -- you must be selective. Your willingness to volunteer may sometimes lead you to take on more than you should.

See how Responsibility shows in your CliftonStrengths results -- discover All 34 CliftonStrengths Themes today !

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Business Journal

The Strengths to Confront Tough Times

Almost daily, companies are cutting workers, and morale and productivity are suffering as a result. In this environment, a strengths-based approach is vital because it creates hope, opens the doors to untapped potential, and brings out the best in people and in companies.

Antimalarial Dual Drugs Based on Potent Inhibitors of Glutathione Reductase from Plasmodium falciparum Wolfgang Friebolin, Beate Jannack, Nicole Wenzel, Julien Furrer, Thomas Oeser, Cecilia P. Sanchez, Michael Lanzer, Vanessa Yardley, Katja Becker and Elisabeth Davioud-Charvet J. Med. Chem. ; (Article) ; 2008 ; 51 (5); 1260–1277. DOI: 10.1021/jm7009292

N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase Aleem Gangjee, Ona O. Adair, Michelle Pagley and Sherry F. Queener J. Med. Chem. ; (Article) ; 2008 ; 51 (19); 6195–6200. DOI: 10.1021/jm800694g

Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation Robert C. Reynolds, Shiela R. Campbell, Ralph G. Fairchild, Roy L. Kisliuk, Peggy L. Micca, Sherry F. Queener, James M. Riordan, W. David Sedwick, William R. Waud, Adelaine K.W. Leung, Richard W. Dixon, William J. Suling, and David W. Borhani J. Med. Chem. ; (Article) ; 2007 ; 50 (14); 3283–3289. DOI: 10.1021/jm0701977

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships Pilho Kim, Sunhee Kang, Helena I. Boshoff, Jan Jiricek, Margaret Collins, Ramandeep Singh, Ujjini H. Manjunatha, Pornwaratt Niyomrattanakit, Liang Zhang, Michael Goodwin, Thomas Dick, Thomas H. Keller, Cynthia S. Dowd and Clifton E. Barry, III J. Med. Chem. ; (Article) ; 2009 ; 52 (5); 1329–1344. DOI: 10.1021/jm801374t

Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5 R )-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli Pilho Kim, Yong-Mei Zhang, Gautham Shenoy, Quynh-Anh Nguyen, Helena I. Boshoff, Ujjini H. Manjunatha, Michael B. Goodwin, John Lonsdale, Allen C. Price, Darcie J. Miller, Ken Duncan, Stephen W. White, Charles O. Rock, Clifton E. Barry, III, and Cynthia S. Dowd J. Med. Chem. ; (Article) ; 2006 ; 49 (1); 159–171. DOI: 10.1021/jm050825p

Synthesis of Natural Product-Inspired Inhibitors of Mycobacterium tuberculosis Mycothiol-Associated Enzymes: The First Inhibitors of GlcNAc-Ins Deacetylase Pilho Kim, Yong-Mei Zhang, Gautham Shenoy, Quynh-Anh Nguyen, Helena I. Boshoff, Ujjini H. Manjunatha, Michael B. Goodwin, John Lonsdale, Allen C. Price, Darcie J. Miller, Ken Duncan, Stephen W. White, Charles O. Rock, Clifton E. Barry, III, and Cynthia S. Dowd J. Med. Chem. ; (Article) ; 2007 ; 50 (25); 6326–6336. DOI: 10.1021/jm070669h

Individuals with 15q24 deletion syndrome are at risk for recurrent chest, upper airway, and ear infections. To date, documented immune deficiency has not been reported in any individual with 15q24 deletion syndrome, however, a referral to immunology may be warranted for recurrent and persistent infections. Referral to otolaryngology is recommended in case of recurrent otitis media and a low threshold is needed for placing pressure equalization (PE) tubes in children with 15q24 deletion syndrome. Recurrent otitis media may also lead to conductive hearing loss, which may affect a child's expressive and receptive language development; therefore, periodic audiologic evaluation is also indicated.

The prognosis for individuals with 15q24 deletion syndrome depends on the severity and extent of congenital malformations. Major birth defects have been reported including, tetralogy of Fallot, myelomeningocele, intestinal atresia, and congenital diaphragmatic hernia (CDH). The prognosis for any individual with CDH is guarded and related to size, location, and visceral involvement of the diaphragmatic hernia [ Essential Top Free Spirit Top by VIDA VIDA Cheap Purchase Cheap Sale Release Dates With Credit Card Cheap Price Free Shipping Visit Ot37EJzb
]. In general, the majority of individuals with 15q24 deletion typically do not have life-threatening organ malformations. The natural history of 15q24 deletion syndrome is currently unknown since there are very few children and even fewer adolescents and adults reported with this deletion. The oldest reported patients, who were 33-years-old at the time of their report, have variable outcome [ TOPWEAR Tshirts Cafènoir Top Quality Cheap Price Footlocker Pictures For Sale Shop Your Own Free Shipping 2018 Discount Buy ekPwTT
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]. The individual reported by Sharp et al. is a 33-year-old male who had mild developmental delay as a child. He has short stature and relatively mild intellectual disability with good language skills as an adult [ 1 ]. Van Esch et al. also reported a 33-year-old male who had severe developmental delay and intellectual disability, hypotonia, and limited speech [ 3 ]. He had hyperactive behavior with aggressive outbursts in childhood and adolescence and remained difficult to handle in adulthood despite psychopharmacological therapy. Longitudinal follow-up of individuals with this deletion will clarify the developmental and functional level of independence that individuals may expect to have in adulthood and possible health-related complications as individuals with this deletion age.

Since 15q24 deletion syndrome is a relatively newly described condition there are still many questions regarding the clinical manifestations that remain unanswered. Salient features that have been reported in a minority of individuals, but have the potential to drastically affect prognosis and anticipatory guidance of individuals with this condition, are the occurrence of neoplasias. At this time, it is unknown if there is a causal relationship between 15q24 deletion and the neoplasias described. Therefore, clinicians should be cognizant of the possible risk of tumors in this population and have low threshold for evaluation if neoplasia is remotely suspected.

The underlying explanation for the discrepancy in the male to female ratio of reported individuals remains unknown. As previously mentioned, this may represent an ascertainment bias rather than a true disparity. A more balanced ratio would be expected as more individuals with 15q24 deletion syndrome are identified.

Lastly, the clinical and phenotypic consequence of the reciprocal duplication of 15q24 remains unknown. Identification of more individuals with 15q24 duplication will enable better classification of clinical features that may be associated with the duplication and a better understanding of the molecular mechanisms that precipitate both the 15q24 deletion and reciprocal duplication.

Further characterization of the clinical phenotype, genotype-phenotype correlations, medical complications, and developmental potential of individuals with 15q24 deletion syndrome is imperative in order to fully comprehend the variability and severity of the syndrome. Natural history studies and longitudinal follow-up by the clinician will provide beneficial information on how children, adolescents, and adults with 15q24 deletion age and progress over time. This could lead to the development of practical screening, management, and surveillance guidelines for any individual diagnosed with 15q24 deletion syndrome.

array comparative genomic hybridization

Meddler

2 children

That was one of the only two abilities shown in the video, no way that was unintended.

I'm on to you rito and your sneaky ways of teasing. And I love every part of it.

King Dellron

1 child

I'm not sure if we expected this dev blog to go out before the mage stuff hit PBE (also this week). All good either way of course, but might not have been a deliberate 'let's give a slightly early glimpse of Vlad's new E' thing.

Meddler

0 children

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You should put the entire list of how all champions fit in their subclasses

Jabalor

5 children

We're working on it at the moment.

Meddler

4 children

Is there an ETA at the moment, or will it be announced later?

Gnart Even Close

1 child

Guessing a few weeks? That's very, very much a guess though, could be significantly earlier or later.

Meddler

0 children

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While you guys work on an official list,I'm sure a few players out there will sort all the champs by subclasses based on the guidelines that were presented here.

N1C Jeddy017

1 child

I hope so!

Really looking forward to seeing how people interpret the roster and how closely that does or doesn't match our own conclusions.

Meddler

0 children

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So... besides rework hell, where does fit into?